Title

AprospectivesafetyandfeasibilitystudyofmeteredcryosprayforpatientswithchronicbronchitisinCOPD

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Background/背景

NocurrentlyapprovedinterventioncounteractsairwaymetaplasiaandmucushypersecretionofchronicbronchitisinCOPD.However,meteredcryospray(MCS)deliveringliquidnitrogentothetracheobronchialairwaysablatesabnormalepitheliumandfacilitateshealthymucosalregeneration.Theobjectiveofthisstudywastoevaluatethefeasibility,efficacyandsafetyofMCSinchronicbronchitis.

目前尚无获批的干预措施可消除COPD中慢性气管炎的气道上皮化和粘液高分泌状态。但是，定量冷冻喷雾（MCS）将液氮输送到气管支气管气道可消融异常上皮并促进健康的粘膜再生。这项研究的目的是评估MCS治疗慢性支气管炎的可行性，有效性和安全性。

Methods/方法

Patientswithaforcedexpiratoryvolumein1?sof30–80%predictedwhoweretakingoptimalmedicationwererecruited.Primaryout